An important aspect of the gerontology research is the identification and analysis of compound that delay aging and extend lifespan; these studies can test theories of aging, lead to discovery of endogenous systems that influence aging and establish the foundation for the treatments that might delay normal human aging. This research article focuses on the various treatments/experiments with the plant adaptogen. Extracts from plant adaptogens such as Withania somnifera (Ashvagandha) have been shown to increase the resistance of a variety of organisms against the damaging effect of different stress conditions. We observed that Ashvagandha extracts also increase the mean lifespan of the nematode Caenorhabditis elegans in a dose-dependent way. Through three independent experiments we found that, 1 mg/ml Withania somnifera significantly increased life span between 28.57% (P<0.0001), increased the maximum lifespan with 3.5-4 days. With higher concentrations, toxic effect was observed, whereas at the highest concentrations tested (2500 µg/ml Withania somnifera) a lifespan shortening effect was observed by 15–25% (P<0.0001). Based on the observation of the present study, it was suggested that adaptogens were practiced as anti-stress agent their optimize concentration increased stress resistance and increase the lifespan of nematode.
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